The mTORC1 complex in pre-osteoblasts regulates whole-body energy metabolism independently of osteoc

• 作 者: Pawanrat Tangseefa Sally K.Mar
• 机 构: AdelaideMedicalSchool,CancerProgram,ResearchCentreforReproductiveHealth,Computational&SystemsBio
• 出 处: 骨研究:英文版
• 发表日期: 2021年1期
• 关键词: METABOLISM mTORC1 HOMEOSTASIS
• 基金项目: the National Health and Medical Research Council of Australia(APP1109207,awarded to ACWZ,PMB,and CGP),Australian Research Council(DP160100454,awarded to ACWZ and PMB),Diabetes Australia Research Progr

Overnutrition causes hyperactivation of mTORC1-dependent negative feedback loops leading to the downregulation of insulin signaling and development of insulin resistance.In osteoblasts(OBs),insulin signaling plays a crucial role in the control of systemic