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目的:探讨参一胶囊对鼻咽癌(nasopharyngeal carcinoma,NPC)患者的放疗敏感性作用。方法:81例接受治疗的患者,随机分入治疗组接受参一胶囊联合放疗或对照组仅放疗。检测两组患者鼻咽活检组织的微血管密度(MVD)情况,分析两组患者放疗疗效及血管内皮生长因子(VEGF)、可溶性细胞黏附因子-1(sICAM-1)、可溶性血管细胞间黏附分子-1(sVCAM-1)表达的差异。结果:治疗组放疗疗效优于对照组(P<0.05)。治疗组MVD、VEGF、sICAM-1、sVCAM-1表达水平均低于对照组(P<0.05)。结论:参一胶囊对于鼻咽癌患者具有放疗增敏作用,其机理可能与抗血管生成作用相关。
Objective: To investigate the effect of Shen-capsule on the radiosensitivity of nasopharyngeal carcinoma (NPC) patients. Methods: A total of 81 patients undergoing treatment were randomized into the treatment group to receive either one capsule combined with radiotherapy or the control group only with radiotherapy. The microvessel density (MVD) of nasopharyngeal biopsies in both groups were detected. The curative effect of radiotherapy and the effects of vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule- 1 (sVCAM-1) expression differences. Results: The curative effect of radiotherapy in treatment group was better than that in control group (P <0.05). The expression of MVD, VEGF, sICAM-1 and sVCAM-1 in the treatment group were lower than those in the control group (P <0.05). Conclusion: Shen-capsule has a radiosensitizing effect on patients with nasopharyngeal carcinoma, the mechanism may be related to anti-angiogenic effect.