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目的 :探讨可逆性后部白质脑病综合征的临床特点。方法 :分析 2 9例可逆性后部白质脑病综合征的临床资料。结果 :2 9例可逆性后部白质脑病综合征中 ,病因为高血压脑病 8例 ,子痫 3例 ,肺部感染伴高血压病 5例 ,使用免疫抑制剂 7例 ,肺癌术后使用化疗药物 3例 ,鼻咽癌放疗 3例。主要临床表现 :嗜睡与昏睡、视力障碍、癫痫发作、记忆力与注意力下降、共济失调、偏瘫。神经影像学以可逆性白质异常病变为特征 ,多数位于半球后部白质。结论 :可逆性后部白质脑病综合征并非所有患者的主要病变位于后部白质 ,部分患者的主要病变位于侧脑室旁、小脑白质与脑干 ,故可改名为可逆性白质脑病综合征较为合适 ,经过正确的治疗 ,患者的症状、体征及神经影像学改变可恢复到病前的水平
Objective: To investigate the clinical features of reversible posterior white matter disease syndrome. Methods: The clinical data of 29 cases of reversible posterior white matter disease syndrome were analyzed. Results: Among the 29 cases of reversible leukoencephalopathy syndrome, the etiology was hypertensive encephalopathy in 8 cases, eclampsia in 3 cases, pulmonary infection in 5 cases with hypertension, immunosupression in 7 cases, postoperative chemotherapy of lung cancer 3 cases of drugs, radiotherapy of nasopharyngeal carcinoma in 3 cases. The main clinical manifestations: lethargy and lethargy, visual impairment, seizures, memory and attention decreased, ataxia, hemiplegia. Neuroimaging is characterized by reversible white matter abnormalities, mostly in the posterior white matter. CONCLUSION: Not all patients with major reversible leukoencephalopathy syndrome are located in the posterior white matter, and some of the major lesion is located beside the lateral ventricle, white matter of cerebellum and brain stem, so it can be renamed reversible leukoencephalopathy syndrome more appropriate, After the correct treatment, the patient’s symptoms, signs and neuroimaging changes can be restored to the pre-disease level