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目的:探讨阿奇霉素长期低剂量口服维持治疗慢性阻塞性肺疾病稳定期患者的临床效果。方法:选择116例COPD稳定期患者为研究对象,随机分为观察组和对照组,每组58例。对照组给予常规基础治疗,观察组在对照组的基础上加用阿奇霉素治疗,随访6个月,观察比较两组治疗前后的肺功能FEV1/FVC值、生活质量评分、呼吸困难评分及不良反应情况。结果:经过治疗,两组患者的肺功能FEV1/FVC值、呼吸困难评分均有所改善,且观察组改善程度优于对照组,差异极显著(P<0.01),具有统计学意义。观察组患者生活质量显著优于对照组,差异极显著(P<0.01),具有统计学意义。结论:低剂量阿奇霉素维持治疗COPD稳定期患者能有效改善患者肺功能及呼吸困难症状,提高其生活质量,且不良反应较轻,安全性高,值得临床推广应用。
Objective: To investigate the clinical effect of azithromycin in long-term low-dose oral maintenance treatment of patients with chronic obstructive pulmonary disease in stable phase. Methods: One hundred and sixty-six patients with stable COPD were selected as study subjects and randomly divided into observation group and control group with 58 cases in each group. The control group was given routine basic treatment. The observation group was treated with azithromycin on the basis of the control group. The patients were followed up for 6 months. The pulmonary function FEV 1 / FVC, quality of life, dyspnea score and adverse reactions before and after treatment were observed and compared . Results: After treatment, the pulmonary function FEV1 / FVC and dyspnea scores improved in both groups, and the improvement in the observation group was better than that in the control group (P <0.01), which was statistically significant. The quality of life of the observation group was significantly better than that of the control group, the difference was significant (P <0.01), with statistical significance. Conclusion: The low-dose azithromycin maintenance treatment of stable COPD patients can effectively improve patients with lung function and dyspnea symptoms, improve their quality of life, and less adverse reactions, high safety, it is worth promoting the clinical application.