经内镜胃粘膜活检单克隆抗体组化染色——附130例慢性萎缩性胃炎结果

• 作 者: 张向阳 汪鸿志 蔡安宁 孙晓华 袁玫 于征 李力 李华
• 机 构: 解放军总医院消化科,解放军总医院消化科,解放军总医院消化科,解放军总医院消化科,解放军总医院肿瘤研究室,解放军总医院肿瘤研究室,解放军总医院肿瘤研究室,解放军总医院肿瘤研究室 100853,10085
• 出 处: 临床消化病杂志
• 发表日期: 1994年02期
• 关键词: 胃粘膜活检 慢性萎缩性胃炎 单克隆抗体 组化染色 消化道肿瘤 共同抗原 早期胃癌 早期癌变 随诊观察 消化道癌

应用本院制备的5种消化道肿瘤单克隆抗体(以下简称单抗);Pc-1,PS-10,Gs-2,Cl-4,Cl-2,对经内镜活检病理证实的130例慢性萎缩性胃炎胃粘膜进行SABC酶联免疫组化染色.上述单抗对慢性萎缩性胃炎的阳性表达率分别为25.4%,21.2%,43.2%,18.6%,31.9%,对5种单抗染色阳性者共55例.密切随诊观察,发现早期癌变2例,另75例染色阴性者尚未发现癌变.染色阳性组伴有肠化者占66.5%.因此分析肿瘤与肠化可能有部分共同抗原物质存在.

Five kinds of digestive tract tumor monoclonal antibodies (Pcb), Pc-1, PS-10, Gs-2, Cl-4 and Cl-2 prepared in our hospital were used in this study. The gastric mucosa of chronic atrophic gastritis were stained with SABC enzyme-linked immunosorbent assay.The positive rates of these McAbs against chronic atrophic gastritis were 25.4%, 21.2%, 43.2%, 18.6%, 31.9%, respectively A total of 55 cases were positive.With the follow-up observation found that 2 cases of early cancer, and the other 75 cases of negative staining have not found cancer.Colorization positive group with intestinal metaplasia accounted for 66.5% .Therefore analysis of tumor and intestinal metaplasia may have some common antigen Material existence.