富含免疫球蛋白M的人静脉免疫球蛋白其防止急性炎症鼠模型的体内外补体激活

• 作 者: 袁彦伯
• 机 构: 广东省人民医院
• 出 处: 国外医学.输血及血液学分册
• 发表日期: 1999年05期
• 关键词: 静脉免疫球蛋白 补体抑制 补体激活 固相聚合 抗炎机制 IgG 体外检测 同型 抑制作用 鼠肾

静脉免疫球蛋白制剂(IVIG)的一种重要抗炎机制是能封闭补体激活。本文旨在比较同型成分的4种不同IVIG制剂其补体抑制活性。这些制剂是:1.IVIgG(48g/L IgG,2g/L IgA;Intraglobin F):2.Pentaglobin(38g/L IgG,6g/L IgM,6g/L IgA);3.IVIgM(35g/L IgM,12g/L IgA,3g/L IgG);4.IVIgA(41g/L IgA,9g/L IgG)均产自德国Biotest Pharma公司。其补体抑制活性的评价用ELISA在体外检测封闭固相聚合兔IgG的C1q-、

An important anti-inflammatory mechanism of intravenous immunoglobulin preparation (IVIG) is the ability to block complement activation. This article aims to compare the complement inhibitory activity of four different IVIG preparations of the same type. These preparations are: 1. IVIgG (48 g / L IgG, 2 g / L IgA; Intraglobin F): 2. Pentaglobin (38 g / L IgG, 6 g / L IgM, 6 g / L IgA); 3. IVIgM , 12 g / L IgA, 3 g / L IgG); 4. IVIgA (41 g / L IgA, 9 g / L IgG) were from Biotest Pharma, Germany. Evaluation of Complement Inhibitory Activity C1q- in which closed-phase solid-phase polymerized rabbit IgG was blocked was detected in vitro by ELISA,