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目的：验证国产α受体阻滞剂乌拉地尔注射液（利喜定）对急重症高血压的降压效果及不良反应。方法：进行多中心平行随机对照开放试验，采用静脉先推后滴方法，同时定时测定患者的收缩压、舒张压及心率变化，并监测患者心电图、血常规、尿常规、血清谷丙转氨酶及尿素氮。结果：本组４１例开放试验，显效１６例（３９．０％），有效２３例（５６．１％），无效２例（４．９％），总有效率９５．ｌ％。用药后平均收缩压下降４３．９７ｍｍＨｇ（Ｐ＜０．００１），平均舒张压下降２８．５６ｍｍＨｇ（Ｐ＜０．００１＝，平均心率下降３．３９次／分（Ｐ＜０．００１＝，用药前后心电图、血常规、尿常规、谷丙转氨酶及尿素氮无异常改变。结论：利喜定对急重症高血压及围手术期高血压是一安全、可靠、速效降压制剂，疗效确切，与其它ａ受体阻断剂相比，无反射性心率加快，未发现对肝肾功能的损害，不良反应小。
Objective: To verify the antihypertensive effects and adverse reactions of domestic α-blocker urapidil injection (Li Xiding) in patients with severe acute hypertension. Methods: A multicenter randomized controlled open trial was conducted. The patients were treated with intravenous injection of propofol and propofol. The systolic blood pressure, diastolic blood pressure and heart rate were measured at the same time. The electrocardiogram, blood routine, urine routine, serum alanine aminotransferase and urea nitrogen. Results: In this group of 41 open trials, 16 (39.0%) were markedly effective, 23 (56.1%) were effective, 2 (4.9%) were ineffective and the total effective rate was 95%. l%. After treatment, the average systolic blood pressure decreased by 43.97mmHg (P <0.001), mean diastolic blood pressure decreased by 28.56mmHg (P <0.001 =, the average heart rate decreased by 3.39 beats / min Before and after electrocardiogram, blood routine, urine routine, alanine aminotransferase and urea nitrogen were no abnormal changes.Conclusion: Li Xiding is a safe, reliable and rapid antihypertensive preparation for acute and severe hypertension and perioperative hypertension, Compared with other a receptor blockers, reflex heart rate was faster, no damage to liver and kidney function was found, and adverse reactions were small.