Interferon-α induced severe thrombocytopenia: A case report and review of the literature

• 作 者: Li Li Da-Kang Han Jun Lu
• 机 构: Tumor Biotherapy Ward of Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
• 出 处: 世界胃肠病学杂志（英文版）
• 发表日期: 2010年11期
• 关键词: Interferon-α Severe thrombocytopenia Chronic hepatitis C

We report a case of severe thrombocytopenia following pegylated interferon-α 2a (Peg-IFN-α 2a) treatment of hepatitis C virus infection and summarize the clinical characteristics of 16 cases of IFN-α induced severe thrombocytopenia and its immune-mediated mechanism. Discontinuation of IFN-α and early administration of immunosuppressants are the effective therapy for IFN-α induced severe thrombocytopenia.