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目的观察低分子肝素联合纳络酮治疗65例急性脑梗死(ACI)临床疗效。方法选择65例急性脑梗死患者,随机分为两组,治疗组35例,对照组30例。对照组30例,入院后均给予右旋糖酐、胞二磷胆碱等治疗,有脑水肿者给予适当脱水,据血压情况适当控制血压。治疗组在常规治疗的基础上,应用国产低分子肝素钠冻干粉(江苏万邦生化医药股份有限公司)5000AXalU,腹壁皮下注射12h 1次,共14d,纳络酮(成都倍特药业有限公司)0.4～0.8mg+5葡萄糖注射液10mL静注,每日2次,连用14d。结果两组患者的血浆β-EP浓度均明显高于正常组,治疗组治疗后,其β-EP浓度显著下降,临床疗效明显高于对照组。提示纳络酮能明显降低(ACI)患者的血浆β-EP浓度。结论低分子肝素钠联合纳络酮治疗急性脑梗死(ACI)有一定疗效。
Objective To observe the clinical effect of low molecular weight heparin combined with naloxone on 65 cases of acute cerebral infarction (ACI). Methods Sixty-five patients with acute cerebral infarction were randomly divided into two groups: 35 cases in the treatment group and 30 cases in the control group. Control group of 30 patients were given dextran, citicoline and other treatment, with cerebral edema were given appropriate dehydration, according to blood pressure control of blood pressure. The treatment group on the basis of conventional treatment, the application of low molecular weight heparin lyophilized powder (Jiangsu Wanbang Biochemical Pharmaceutical Co., Ltd.) 5000AXalU, abdominal subcutaneous injection of 12h 1, a total of 14d, naloxone (Chengdu times special Pharmaceutical Co., Ltd. ) 0.4 ~ 0.8mg + 5 glucose injection 10mL intravenously, 2 times a day, once every 14d. Results The plasma β-EP levels in both groups were significantly higher than those in the normal group. The β-EP concentration in the treatment group decreased significantly after treatment, and the clinical efficacy was significantly higher than that in the control group. Tip Naloxone can significantly reduce (ACI) in patients with plasma β-EP concentration. Conclusion Low molecular weight heparin combined with naloxone in the treatment of acute cerebral infarction (ACI) has a certain effect.