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用免疫印迹技术(IBT)对150例系统性红斑狼疮(SLE)活动期患者进行了7种可提取性核抗原(ENA)自身抗体的检测。130例(86.7％)患者检出至少一种自身抗体。抗Sm抗体的阳性率达51.3％(77例);抗Ro抗体阳性率为18.7％(28例),抗核糖体抗体阳性率为17.3％(26例)。临床应用表明IBT具有快速、简便、敏感、稳定和精确等优点。对SLE患者IBT检测7种抗体与荧光ANA及LBT的关系进行了讨论。
Immunohistochemistry (IBT) was performed on 150 patients with active systemic lupus erythematosus (SLE) for the detection of seven extractable nuclear antigen (ENA) autoantibodies. One hundred thirty (86.7%) patients detected at least one autoantibody. The positive rate of anti-Sm antibody was 51.3% (77 cases), the positive rate of anti-Ro antibody was 18.7% (28 cases) and the anti-ribosomal antibody was 17.3% (26 cases). Clinical application shows that IBT has the advantages of fast, simple, sensitive, stable and accurate. The relationship between seven antibodies detected by IBT in SLE patients and fluorescent ANA and LBT was discussed.