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Pritchard等子1954年描述一组有溶血、血小板减少和血凝异常的特殊严重妊毒症病人.Weinstein命名为HELLP综合征.(即溶血、肝酶升高和低血小板计数).作者近10年内收130例严重先兆子痫病人(血压≥160/110mmHg及蛋白尿),发现其中12例符合上述HELLP综合征.就其血小板计数,血浆纤维蛋白原、纤维蛋白原单体复合物和抗凝血酶Ⅲ的浓度;肝脏谷丙转氨酶和谷草转氨酶的活性;肾活检所见及围产期结果等参数与另118例无此综合征的
Pritchard et al. Described a group of patients with particularly severe forms of hemolysis, thrombocytopenia and abnormal hemagglutination in 1954. Weinstein is named HELLP syndrome (ie hemolysis, elevated liver enzymes, and low platelet count). In the last 10 years 130 patients with severe preeclampsia (blood pressure ≥160 / 110mmHg and proteinuria) were collected and 12 of them were found to be eligible for HELLP syndrome.The platelet count, plasma fibrinogen, fibrinogen monomer complex and antithrombin Ⅲ concentration; liver alanine aminotransferase and aspartate aminotransferase activity; renal biopsy findings and perinatal outcome parameters and the other 118 cases without this syndrome