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目的探讨血清胱抑素C(Cys-C)水平变化及对糖尿病肾病(DN)患者早期诊断的价值。方法检测112例糖尿病患者血清Cys-C,就其在DN发生发展中的水平变化、作用及对临床的早期诊断价值进行评价。结果糖尿病组Cys-C明显高于正常对照组(P<0.01),且随着尿蛋白的增加而升高。结论检测血Cys-C可作为诊断DN早期肾损伤的有效指标,可应用于DN进展监测及疗效观察。
Objective To investigate the changes of serum cystatin C (Cys-C) level and its value in the early diagnosis of diabetic nephropathy (DN). Methods Serum Cys-C levels were measured in 112 patients with diabetes mellitus (DM). The levels of Cys-C in the development and progression of DN and the clinical value of early diagnosis were evaluated. Results Cys-C in diabetic group was significantly higher than that in normal control group (P <0.01), and increased with the increase of urinary protein. Conclusion Detection of blood Cys-C can be used as an effective indicator of early diagnosis of DN renal damage, can be applied to monitor the progress of DN and efficacy.