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目的研究E838对辐射暴露小鼠造血功能的防护作用。方法用内源性脾结节形成(CFU-S),股骨有核细胞(BMN)计数及脾脏指数等方法观察E838、炔雌醇、尼尔雌醇对137Csγ射线照射7.5Gy小鼠造血功能的影响。观察受照小鼠的BMN、CFU-S和脾指数的变化。结果照射后第9天E838各组的BMN数、CFU—S及脾脏指数与对照组相比有明显的增高,经统计学处理差异有显著性(P<0.001)。E838三个剂量组的BMN数与尼尔雌醇组比较有所上升,差异有显著性(P<0.001),与炔雌醇比较,中、高剂量组差异有显著性(P<0.05)。E838三个剂量组的脾脏指数与尼尔雌醇组和对照组相比较,差异有显著性(P<0.001),结论E838对辐射暴露小鼠造血系统具有保护作用。
Objective To study the protective effect of E838 on the hematopoietic function in irradiated mice. Methods CFU-S, BMN count and spleen index were used to observe the effects of E838, ethinyl estradiol and nylestriol on the hematopoietic function of 137Cs γ-ray irradiated 7.5 Gy mice influences. The changes of BMN, CFU-S and spleen index in irradiated mice were observed. Results On the 9th day after irradiation, the number of BMN, CFU-S and spleen index in E838 group were significantly higher than those in control group, and the difference was statistically significant (P <0.001). The number of BMNs in three dose groups of E838 increased compared with that in nilestriol group (P <0.001). Compared with ethinyl estradiol, the number of BMN in middle dose group and high dose dose group was significantly different (P <0.05). E838 spleen index of the three dose groups compared with the nilestriol group and the control group, the difference was significant (P <0.001), Conclusion E838 on radiation-exposed mouse hematopoietic system has a protective effect.