论文部分内容阅读
目的:探讨IGF-1对学龄前阻塞性睡眠呼吸暂停综合征(OSAS)儿童认知能力的影响。方法:对OSAS组52例和对照组49例学龄前儿童进行多导睡眠监测,利用韦氏记忆量表、韦氏儿童智力测验量表和图形划销测验进行认知能力评定。血清IGF-1浓度测定采用放射免疫分析方法,同时对血清IGF-1浓度与记忆能力、智商和注意力进行相关性分析。结果:OSAS组记忆能力(数字顺背、数字倒背、数字广度测验合计)和总智商均明显低于对照组(P<0.05)。OSAS组注意力失误分明显高于对照组(P<0.05)。OSAS组血清IGF-1浓度明显低于对照组(P<0.05)。血清IGF-1浓度与数字广度测验合计分数及总智商呈正相关,与注意力失误分呈负相关。结论:学龄前阻塞性睡眠呼吸暂停综合征儿童存在记忆能力、智力水平和注意力方面的认知功能障碍;IGF-1水平的下降是引起认知功能障碍的机制之一。
Objective: To investigate the effect of IGF-1 on cognition in pre-school children with obstructive sleep apnea syndrome (OSAS). Methods: Polysomnography was performed on 52 preschool children in OSAS group and 49 preschool children in control group. The cognitive ability was assessed by Wechsler Memory Scale, Webster Children’s Intelligence Test Scale and graphic demarcation test. Serum IGF-1 levels were measured by radioimmunoassay, and correlation analysis between serum IGF-1 concentration and memory, IQ, and attention was performed. Results: The scores of memory (total number of digits, total number of digits, number of breadth test) and total IQ of OSAS group were significantly lower than those of control group (P <0.05). OSAS group attention errors were significantly higher than the control group (P <0.05). The level of serum IGF-1 in OSAS group was significantly lower than that in control group (P <0.05). Serum IGF-1 concentration was positively correlated with the total score of digital breadth test and total intelligence, and was negatively correlated with attention deficit score. Conclusion: Children with preschool sleep apnea syndrome have cognitive dysfunction in memory, intelligence and attention. The decline of IGF-1 level is one of the mechanisms that cause cognitive dysfunction.