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目的检测过敏性紫癜患儿血清抗内皮细胞抗体(AECA)水平,探讨其在HSP发病机制中的作用。方法 2010年6月至2011年1月在温州医学院附属育英儿童医院肾脏科住院的过敏性紫癜患儿(HSP)60例,分为紫癜性肾炎(HSPN)组40例和非HSPN组20例,按病程分为急性期和缓解期,另以20名健康儿童作为对照组。应用酶联免疫吸附法(ELISA)检测血清AECA水平。结果对照组血清AECA为(232.31±53.89)ng/mL。HSP患儿急性期为(355.18±58.07)ng/mL,与对照组比较,差异有统计学意义(P<0.01);缓解期为(243.19±58.68)ng/mL,与对照组比较,差异无统计学意义(P>0.05),与急性期比较,差异有统计学意义(P<0.01)。非HSPN组急性期为(328.09±57.97)ng/mL,HSPN组为(369.66±59.20)ng/mL,差异有统计学意义(P<0.05)。结论 AECA可能参与了HSP血管损伤的病理过程,检测AECA可作为判断HSP病情的指标。
Objective To detect the level of serum anti-endothelial cell antibody (AECA) in children with Henoch-Schonlein purpura and to explore its role in the pathogenesis of HSP. Methods From June 2010 to January 2011, 60 children with Henoch-Schonlein purpura (HSP) hospitalized in Department of Nephrology, Yuying Children’s Hospital Affiliated to Wenzhou Medical College were divided into 40 cases of HSPN group and 20 cases of non-HSPN group , According to the course of the disease is divided into acute and remission, another with 20 healthy children as a control group. Serum AECA levels were measured by enzyme-linked immunosorbent assay (ELISA). Results The serum AECA in the control group was (232.31 ± 53.89) ng / mL. The acute stage of HSP was (355.18 ± 58.07) ng / mL, which was significantly different from the control group (P <0.01). The remission period was (243.19 ± 58.68) ng / mL. Compared with the control group, Statistical significance (P> 0.05), compared with the acute phase, the difference was statistically significant (P <0.01). The acute phase of non-HSPN group was (328.09 ± 57.97) ng / mL, and the HSPN group was (369.66 ± 59.20) ng / mL, the difference was statistically significant (P <0.05). Conclusion AECA may be involved in the pathological process of HSP vascular injury, detection of AECA can be used as indicators to determine the severity of HSP.