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目的:观察妥洛特罗贴剂治疗轻中度儿童支气管哮喘的疗效和安全性。方法:98例轻、中度儿童支气管哮喘患儿随机分为两组,观察组给予妥洛特罗贴剂0.5mg,每日2贴,同时吸入丙酸氟替卡松125～250μg·d~(-1),对照组吸入沙美特罗/氟替卡松150～300μg·d~(-1)。治疗前后测量用力肺活量(FVC)和第1秒用力呼气容积(FEV_1)及呼气峰流量(PEF)晨间及睡前的变化记录;采用St George’s呼吸疾病问卷(SGRQ)测评患儿生活质量,根据症状评分判断呼吸困难等指标的改善,并对不良事件进行监测及记录。结果:观察组治疗结束时PEF值、症状评分均显著改善,用药次数、夜间憋醒次数减少,与对照组比较,差异有统计学意义(P<0.05)。两组FEV_1值及不良反应比较,差异无统计学意义(P>0.05)。结论:妥洛特罗贴剂治疗儿童轻、中度支气管哮喘有效、安全,依从性好。
Objective: To observe the efficacy and safety of tulobuterol patch in the treatment of bronchial asthma in children with mild to moderate disease. Methods: A total of 98 mild and moderate children with bronchial asthma were randomly divided into two groups. The observation group was treated with 0.5 mg tulobuterol patch, 2 sticks per day, while fluticasone propionate 125 ~ 250 μg · d ~ (-1) ), And the control group received salmeterol / fluticasone 150 ~ 300μg · d ~ (-1). Changes of forced vital capacity (FVC), FEV 1 and PEF in morning and at bedtime before and after treatment were recorded. St George’s respiratory disease questionnaire , According to the symptom score to determine the improvement of indicators such as dyspnea, and monitoring and recording of adverse events. Results: At the end of treatment, the PEF value and symptom score of the observation group were significantly improved. The number of medication and the number of nighttime arousal decreased. Compared with the control group, the difference was statistically significant (P <0.05). There were no significant differences in FEV_1 values and adverse reactions between the two groups (P> 0.05). Conclusion: The use of tulobuterol patch in children with mild to moderate bronchial asthma is effective, safe and good compliance.