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包含氧化还原酶的WW结构域(WW domain containing oxidoreductase,WWOX)基因是2000年由Bednarek和Ried等同时发现的一个新的候选抑癌基因[1],它位于染色体16q23.3-24.1区域,即普通型脆性位点FRA16D上。这个特殊位置使其近年来颇受重视,人们希望能通过研究它的表达与肿瘤发生的
The WW domain containing oxidoreductase (WWOX) gene is a new candidate tumor suppressor gene discovered simultaneously by Bednarek and Ried in 2000 [1]. It is located in the region of chromosome 16q23.3-24.1 Ordinary brittle site FRA16D on. This special position has given its attention in recent years, people hope that by studying its expression and tumor development