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目的:观察中药调理联合降脂干预对颈动脉粥样硬化性狭窄患者颈动脉支架植入术后的影响。方法:选取2013年1月~2016年1月在我院治疗的颈动脉狭窄患者83例,所有患者行颈动脉支架植入术,且手术成功,然后将患者随机分为观察组(n=44)和对照组(n=39),观察组给予中药调理联合降脂干预,对照组给予降脂干预,观察两组血脂、颈动脉内膜厚度及再次狭窄发生情况。结果:观察组干预后总胆固醇(TC)、甘油三脂(TG)和高密度脂蛋白胆固醇(HDL-C)分别为(3.67±0.82)mmol/L、(1.18±0.40)mmol/L和(1.81±0.31)mmol/L,明显低于对照组(P<0.05),而低密度脂蛋白胆固醇(LDL-C)为(1.61±0.41)mmol/L,明显高于对照组(P<0.05);观察组干预后颈动脉内膜中层厚度为(1.17±0.42)mm,明显低于对照组(P<0.05);观察组再次狭窄发生率为13.64%,明显低于对照组的33.33%,差异比较有统计学意义(P<0.05);随访期间两组无不良反应发生。结论:颈动脉粥样硬化性狭窄患者颈动脉支架植入术后,应用中药调理联合降脂干预,可明显降低血脂水平,减少颈动脉再次狭窄的发生。
Objective: To observe the effects of traditional Chinese medicine and lipid-lowering intervention on carotid artery stenting in patients with carotid atherosclerosis. Methods: 83 patients with carotid artery stenosis treated in our hospital from January 2013 to January 2016 were enrolled in this study. All patients underwent carotid artery stenting and the operation was successful. The patients were then randomly divided into observation group (n = 44) ) And control group (n = 39). The observation group was treated with traditional Chinese medicine in combination with lipid-lowering intervention. The control group was given lipid-lowering intervention. The levels of blood lipid, carotid intima-media thickness and restenosis in the two groups were observed. Results: The total cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) in observation group were (3.67 ± 0.82) mmol / L and 1.81 ± 0.31 mmol / L, significantly lower than that of the control group (P <0.05), while LDL-C was significantly higher than that of the control group (1.61 ± 0.41 mmol / L, P < . The carotid intima-media thickness in the observation group was (1.17 ± 0.42) mm, significantly lower than that in the control group (P <0.05). The incidence of restenosis in the observation group was 13.64%, which was significantly lower than that in the control group (33.33% (P <0.05). No adverse reactions occurred in both groups during follow-up. Conclusion: Carotid artery stenting in patients with carotid atherosclerosis should be treated with traditional Chinese medicine in combination with lipid-lowering intervention, which can significantly reduce blood lipid levels and reduce the restenosis of carotid artery.