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目的:评价左旋甲状腺素钠对妊娠合并甲状腺功能减退症患者子代智力、发育的影响。方法:选取濮阳市妇幼保健院2015年6月至2016年12月收治的妊娠合并甲状腺功能减退患者120例,根据随机数表法分为观察组及对照组,各60例。对照组不实施药物治疗,观察组使用左旋甲状腺素钠治疗,观察并比较两组产妇妊娠期并发症及子代智力、发育情况。结果:观察组妊娠期贫血、高血压发病率低于对照组,早产发生率低于对照组,差异具有统计学意义(P<0.05);观察组儿童1岁的智力及发育水平均明显高于对照组,差异具有统计学意义(P<0.05)。结论:左旋甲状腺素钠治疗妊娠合并甲状腺功能减退症,产妇妊娠期合并症发生风险低,子代智力的发育情况好,临床治疗效果显著。
Objective: To evaluate the effect of L-thyroxine sodium on the intelligence and development of offspring in pregnancy complicated with hypothyroidism. Methods: One hundred and twenty cases of hypothyroidism with pregnancy were selected from June 2015 to December 2016 in Puyang MCH. According to the random number table, the patients were divided into observation group and control group, 60 cases each. The control group did not implement drug treatment, the observation group using levothyroxine sodium treatment, observe and compare the two groups of maternal complications and offspring intelligence, development. Results: The incidence of anemia and hypertension during pregnancy in observation group was lower than that in control group, the incidence of preterm birth was lower than that in control group, the difference was statistically significant (P <0.05); the intelligence and development of children in observation group were significantly higher than those of control group Control group, the difference was statistically significant (P <0.05). Conclusion: L-thyroxine sodium treatment of pregnancy complicated with hypothyroidism, maternal pregnancy complications are low risk of development of children’s intelligence is good, the clinical treatment effect is significant.