论文部分内容阅读
目的探讨男女人群高尿酸血症(HUA)与代谢综合征(MS)的关系,为HUA的预防及临床治疗提供依据。方法以2011年安徽省某农场2 742名健康体检者为研究对象,调查男女人群HUA及MS各组分的检出情况;比较男女在不同年龄段HUA以及MS的检出率;男女分别根据血尿酸(SUA)浓度四分位数分组,比较各组MS的检出率;应用多因素非条件logistic回归分别分析男、女HUA的影响因素。结果研究人群HUA的检出率为10.8%,其中男性为14.1%,女性为7.6%;MS的检出率为13.4%,其中男性为18.8%,女性为8.0%。男性HUA、MS检出率均高于女性,差异有统计学意义(χ2值分别为34.56和74.32,P<0.05)。年龄分层分析显示,随年龄增长,男性HUA检出率上升趋势不明显(趋势χ2=4.36,P>0.05);女性HUA检出率上升趋势明显(趋势χ2=37.66,P<0.05)。随年龄增长,男、女MS的检出率均呈升高趋势(男、女趋势χ2值分别为7.30、17.36,P<0.05)。根据SUA浓度四分位数分组,随着SUA浓度增加,男、女人群中MS的检出率(男性分别为17.9%、11.5%、14.6%、25.4%,女性分别为3.4%、7.4%、16.7%、19.6%)均呈上升趋势(趋势χ2值分别为16.78和14.56,P<0.05),女性较男性表现更加明显。男、女HUA组中高甘油三酯(TG)、高收缩压(SBP)、高舒张压(DBP)、超重或肥胖检出率均显著高于正常血尿酸(NU)组,差异有统计学意义(P<0.01)。多因素非条件logistic回归分析发现,男性HUA与体质指数(BMI)、DBP、TG具有独立相关性(OR值分别为1.54、1.92、2.14,P<0.01),女性HUA与BMI、SBP、TG具有独立相关性(OR值分别为1.93、2.32、2.01,P<0.01)。结论不同性别人群SUA水平均与MS水平密切相关,女性SUA水平与MS的关系更为密切。
Objective To investigate the relationship between hyperuricemia (HUA) and metabolic syndrome (MS) in both men and women and to provide evidence for the prevention and clinical treatment of HUA. Methods A total of 2 742 healthy subjects in a farm in Anhui Province in 2011 were investigated to investigate the detection of HUA and MS in both sexes. The detection rates of HUA and MS in men and women at different ages were compared. Uric acid (SUA) concentration quartiles were divided into groups to compare the detection rate of MS in each group. Multivariate non-conditional logistic regression analysis was used to analyze the influencing factors of male and female HUA respectively. Results The prevalence of HUA in the study population was 10.8%, of whom 14.1% for males and 7.6% for females; the detection rate of MS was 13.4%, of whom 18.8% were males and 8.0% females. The detection rates of HUA and MS in males were higher than those in females (χ2 = 34.56 and 74.32, respectively, P <0.05). Hierarchical analysis of age showed that with the increase of age, the detection rate of HUA was not obvious (trend χ2 = 4.36, P> 0.05). The detection rate of HUA increased significantly in women (trend χ2 = 37.66, P <0.05). With the increase of age, the detection rates of MS and MS were all increased (male and female trend χ2 values were 7.30,17.36, P <0.05). According to the quartile of SUA group, the detection rate of MS in male and female groups increased with the increase of SUA concentration (male: 17.9%, 11.5%, 14.6%, 25.4%, 3.4%, 7.4% 16.7%, 19.6%) showed an upward trend (trend χ2 values were 16.78 and 14.56, P <0.05), the performance of women more than men. The detection rates of TG, SBP, DBP, overweight or obesity in HUA group were significantly higher than those in normal uric acid group (P <0.01). Multivariate non-conditional logistic regression analysis showed that male HUA was independently associated with body mass index (BMI), DBP and TG (OR = 1.54, 1.92, 2.14, P <0.01) (OR = 1.93, 2.22, 2.01 respectively, P <0.01). Conclusions SUA levels in different gender groups are closely related to MS levels, and female SUA levels are more closely related to MS.