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以光系统Ⅱ抑制剂DISCO(DIStance COmparisons)模型的活性构象分子作为模板,利用比较分子场分析方法对三类结构不同的化合物进行了三维构效关系的研究。研究结果有助于对DISCO重叠模型的评估和新型PSⅡ抑制剂的设计与合成。
The structure-activity relationship of three compounds with different structures was investigated by comparative molecular field analysis using the active conformational molecules of the DISCO (DIStance (CO) -Disimilars model) as a template. The results contribute to the evaluation of the DISCO overlap model and the design and synthesis of new PS II inhibitors.