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目的观察伊立替康(艾力、CPT-11)及氟尿嘧啶(5-Fu)和四氢叶酸钙(CF)组成的IFL方案治疗晚期胃癌的近期疗效及安全性。方法晚期胃癌患者共33例,采用上述三药联合化疗,即艾力100 mg/m2,静脉滴注,第1天;CF 100 mg/d,静脉滴注,第1~5天;5-Fu 500 mg/m2,持续静脉滴注4~6 h,第1~5天;3周为1周期,至少2个周期后按照WHO标准评估疗效及毒性反应。结果全组33例均可评价,CR 0例,PR 12例,SD 14例,PD 7例,有效率36.4%。中位疾病进展时间(TTP)4.7个月,中位生存时间(MST)7.3个月。主要不良反应为恶心、呕吐、迟发性腹泻和骨髓抑制等。结论艾力+5-Fu/CF治疗晚期胃癌疗效确切,毒副反应可以耐受,值得临床继续应用。
Objective To observe the short-term efficacy and safety of IFL regimen consisting of irinotecan (CPT-11), 5-fluorouracil (5-Fu) and calcium folinate (CF) in the treatment of advanced gastric cancer. Methods A total of 33 patients with advanced gastric cancer were enrolled in this study. All the above three drugs were used in combination with chemotherapy, namely, Ai Li 100 mg / m2, intravenous drip, on the first day, CF 100 mg / d, intravenous drip on day 1 to 5, 500 mg / m2, continuous intravenous infusion of 4 ~ 6 h, 1 to 5 days; 3 weeks for 1 cycle, at least 2 cycles after the evaluation of efficacy and toxicity according to WHO criteria. Results All the 33 cases were evaluable. There were 0 cases in CR, 12 cases in PR, 14 cases in SD and 7 cases in PD, the effective rate was 36.4%. The median time to progression (TTP) was 4.7 months and the median survival time (MST) was 7.3 months. The main adverse reactions were nausea, vomiting, delayed diarrhea and bone marrow suppression. Conclusion The efficacy of AI + 5-Fu / CF in the treatment of advanced gastric cancer is accurate and the toxic and side effects can be tolerated. It is worth further clinical application.