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目的探讨手术前新辅助化疗联合放射治疗治疗局部晚期宫颈癌的疗效。方法分析35例Ⅰb2期～Ⅱb2期术前新辅助化疗联合放射治疗(观察组)与32例单纯手术(对照组)的局部晚期宫颈癌患者的临床资料,评价观察组和对照组患者的近期疗效,并比较两组患者术中出血量、手术时间、术后病理特征与疗效。结果观察组患者治疗总有效率为80.9%,高于对照组的9.3%(P<0.05)。两组患者手术时间、术中出血量、脉管受侵以及阴道切缘癌残留率比较,差异无统计学意义(P>0.05),观察组患者宫旁浸润率及淋巴结转移率低于手术组(P<0.05)。结论手术前新辅助化疗联合放射治疗可以缩小局部肿瘤,使宫旁浸润消退,可提高局部晚期宫颈癌的疗效。
Objective To investigate the effect of preoperative neoadjuvant chemotherapy combined with radiotherapy in the treatment of locally advanced cervical cancer. Methods The clinical data of 35 patients with stage Ⅱb2 ~ Ⅱb2 preoperative neoadjuvant chemotherapy combined with radiotherapy (observation group) and 32 patients with surgery alone (control group) of locally advanced cervical cancer were analyzed in order to evaluate the short-term curative effect of observation group and control group The blood loss, operation time, postoperative pathological features and curative effect were compared between the two groups. Results The total effective rate of observation group was 80.9%, higher than that of the control group (9.3%, P <0.05). There was no significant difference in the operation time, intraoperative blood loss, vascular invasion and vaginal margin cancer residual rate between the two groups (P> 0.05). The infiltration rate of the uterus and the rate of lymph node metastasis in the observation group were lower than those in the operation group (P <0.05). Conclusions Neoadjuvant chemotherapy combined with radiotherapy before operation can reduce the local tumor, make the uterine infiltration subside and improve the curative effect of locally advanced cervical cancer.