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恶性肿瘤的发病率正在逐年上升,成为危害人类生命的第二大死亡原因。肺癌是最常见致命的癌症之一,但目前临床上发现的患者多为中晚期肺癌患者,预后差。近期资料显示,仅10％非小细胞肺癌(NSCLC)和3％小细胞肺癌(SCLC)能长期生存。目前,已发现神经肽是肿瘤生长的重要调节物,许多非上应性肿瘤均可产生肽类激素。内皮素-1(ET-1)和降钙素基因相关肽(CGRP)为其中的两种,它们均可通过自分泌和旁分泌的方式作用
The incidence of malignant tumors is increasing year by year, becoming the second leading cause of death that endangers human life. Lung cancer is one of the most common and deadly cancers, but most of the patients currently found clinically have advanced lung cancer with poor prognosis. Recent data show that only 10% of non-small cell lung cancer (NSCLC) and 3% of small cell lung cancer (SCLC) can survive long term. At present, neuropeptides have been found to be important regulators of tumor growth and many non-responsive tumors produce peptide hormones. Endothelin-1 (ET-1) and calcitonin gene-related peptide (CGRP) are two of them, both of which can act through autocrine and paracrine