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[目的]观察克拉霉素联合三联疗法对幽门螺杆菌(Hp)相关胃炎的疗效及对Hp的影响。[方法]将160例Hp相关胃炎患者按照不同治疗方式分为研究组与对照组(每组80例),对照组行三联疗法(奥美拉唑+阿莫西林+甲硝唑)治疗,研究组行克拉霉素+三联疗法治疗,观察并比较2组临床疗效、Hp转阴率及血清指标水平变化情况。[结果]研究组临床治疗总有效率96.25%及Hp转阴率98.75%均显著高于对照组的81.25%、82.50%,差异均有统计学意义(P<0.05,P<0.01);2组治疗后血清指标均较治疗前有明显改善,但研究组改善更显著,组内、组间比较差异均具统计学意义(P<0.05,P<0.01)。[结论]Hp相关胃炎行克拉霉素联合三联疗法治疗效果良好,同时可促进Hp转阴,改善血清指标水平,具有临床实际应用价值。
[Objective] To observe the curative effect of clarithromycin combined with triple therapy on Helicobacter pylori (Hp) -related gastritis and its effect on Hp. [Methods] 160 Hp-related gastritis patients were divided into study group and control group (80 cases in each group) according to different treatment methods. The control group was treated with triple therapy (omeprazole + amoxicillin + metronidazole) Group clarithromycin + triple therapy, observed and compared two groups of clinical efficacy, Hp conversion rate and serum levels of indicators of change. [Results] The total effective rate of clinical treatment and the rate of negative conversion rate of Hp in study group were significantly higher than 81.25% and 82.50% in control group (P <0.05, P <0.01) After treatment, serum indexes were significantly improved compared with those before treatment, but the improvement in the study group was more significant. There were significant differences between the two groups (P <0.05, P <0.01). [Conclusion] The treatment of Hp-associated gastritis with clarithromycin combined with triple therapy has a good effect. At the same time, it can promote the negative conversion of Hp and improve the level of serum indexes, which is of clinical value.