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目的了解肾病患者红细胞免疫功能变化及与循环免疫复合物改变之间的关系。方法采用红细胞花环实验和免疫比浊法检测112例肾病患者红细胞C3b受体花环率与红细胞免疫复合物花环率及循环免疫复合物水平,并与40例正常对照相比。结果慢性肾炎组肾病综合症组及其它肾病组红细胞C3b受体花环率明显降低,同时伴有红细胞免疫复合花环率升高肾病综合症患者循环免疫复合物水平明显高于正常人及其它肾病组。结论肾病患者红细胞免疫功能降低,循环免疫复合物含量的改变,可能在肾病的发生发展过程中起重要作用。
Objective To understand the relationship between the changes of erythrocyte immune function and the changes of circulating immune complex in patients with nephropathy. Methods The erythrocyte C3b receptor rosette rate, erythrocyte immune complex rosette rate and circulating immune complex level in 112 patients with nephropathy were detected by erythrocyte rosette assay and immunoturbidimetry, and compared with 40 normal controls. Results In the nephrotic syndrome group and other nephrotic groups, the level of C3b receptor rosette in chronic nephritic group was significantly lower than that in normal nephropathy group and nephrotic syndrome group. Conclusion The decrease of erythrocyte immune function and the change of circulating immune complex in patients with nephropathy may play an important role in the occurrence and development of nephropathy.