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对68例膀胱癌病人采用尿脱落细胞吖啶橙染色荧光显微镜检查(AO-F),阳性率达83.8%,对照组34例,未发现阳性。AO-F 方法突破了单从细胞形态检测肿瘤细胞的传统方法,利用较肿瘤细胞出现为早的细胞化学的核酸代谢变化鉴别癌细胞,对早期诊断膀胱癌具有重要的临床应用价值.
Urinary exfoliated cells were stained with acridine orange fluorescence microscopy (AO-F) in 68 cases of bladder cancer. The positive rate was 83.8%. In the control group, 34 cases were positive. The AO-F method breaks through the traditional method of single detection of tumor cells from the cell morphology. Identifying the cancer cells by the change of the nucleic acid metabolism which occurs earlier than the tumor cells shows an important clinical value in the early diagnosis of bladder cancer.