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目的:探讨嗅球结构体积在原发性帕金森病(Parkinson’s disease)和正常人的差异。方法:20列原发性帕金森病患者以及12列年龄匹配的志愿者被选入本次实验,分别对他们进行Hoehn-Yahr分级,帕金森病统一评价量表(UPDRS),左右侧肢体功能评分,简易精神状态量表(MMSE),蒙特利尔认知评估(MOCA)和磁共振成像检查。结果:正常对照组与帕金森病患者组的嗅球体积有统计学差异,帕金森病患者的嗅球体积与左右侧肢体运动功能评分、UPDRS评分、Hoehn-Yahr分级、MMSE、MOCA无明显相关性,但与患者的病程有显著相关性。结论:利用高分辨率磁共振成像计算嗅球嗅束体积能够作为帕金森病患者的早期诊断指标之一。
Objective: To investigate the difference of the volume of olfactory bulb structure between primary Parkinson’s disease and normal subjects. METHODS: Twenty patients with primary Parkinson’s disease and 12 age-matched volunteers were enrolled in this study. Hoehn-Yahr classification, Parkinson’s disease uniformed rating scale (UPDRS), left and right limb function Score, MMSE, Montreal Cognitive Assessment (MOCA), and magnetic resonance imaging. Results: The volume of olfactory bulb in normal control group and Parkinson’s disease group were statistically different. The volume of olfactory bulb in patients with Parkinson’s disease had no significant correlation with left and right limb motor function score, UPDRS score, Hoehn-Yahr grade, MMSE, MOCA, But with the patient’s course of a significant correlation. CONCLUSIONS: The use of high-resolution magnetic resonance imaging to calculate the volume of the olfactory bulb in olfactory bulb can be one of the early diagnostic criteria for Parkinson’s disease.