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目的对顽痛灵外用治疗癌性疼痛的疗效特点进行系统的临床观察。方法选取2010年5月至2011年12月间收入我院的200例诊断明确的中重度癌性疼痛患者,予以1987年WHO的癌症疼痛评分标准评分后随机分为观察组和对照组。观察组采用中频导入顽痛灵搽剂同时口服美施康定治疗癌痛,对照组常规服用美施康定镇痛。7d为一评价疗程。分别观察两组镇痛起效时间、持续止痛时间、美施康定用量、治疗后总有效率、显著缓解率、生活质量评分、抑郁自评量表评分(SDS)、用药满意度、毒副反应等,并进行治疗后组间比较,分析其统计学意义。结果采用了观察组起效时间明显较使用美施康定为少,且镇痛有效时间明显增加(P<0.05),两组治疗镇痛效果总有效率可达到90%以上,且显著有效率也大于85%,两组间无统计学差异(P>0.05),观察组的患者生活质量评分明显高于对照组(P<0.05),用药满意度也明显较对照组高(P<0.05)。观察组出现的毒副作用叫对照组明显少(P<0.05)。结论采用中频导入顽痛灵搽剂+口服美施康定能起到快速镇痛,镇痛持久,毒副作用少,患者用药满意度高切经济适用等优点,值得临床推广。
Objective To investigate the curative effect of topical painkiller treatment of cancer pain. Methods A total of 200 patients with moderately and severely diagnosed cancerous pain who were admitted to our hospital from May 2010 to December 2011 were selected and randomly divided into observation group and control group according to the 1987 WHO criteria for cancer pain score. The observation group was treated with mid-frequency induction of Tongtongling liniment while oral administration of Meishi Kangding for the treatment of cancer pain, and the control group was given Meishi Kangding analgesia routinely. 7d for a review of treatment. The duration of analgesia, the duration of analgesia, the amount of mesylate used, the total effective rate after treatment, the rate of significant response, the quality of life score, SDS, drug satisfaction, side effects After treatment, the comparison between groups was made and the statistical significance was analyzed. The results using the observation group onset time was significantly less than the use of methoximate and analgesic effective time was significantly increased (P <0.05), the two groups the total effective rate of analgesic effect can reach more than 90%, and the remarkable efficiency (P> 0.05). The quality of life of patients in the observation group was significantly higher than that of the control group (P <0.05), and the drug satisfaction was also significantly higher than that of the control group (P <0.05). The side effects observed in the observation group were significantly less in the control group (P <0.05). Conclusions The introduction of intravesical instillation of Tongtongling liniment and oral administration of Meishi Kangding can promote rapid analgesia, long lasting analgesia, less toxic and side effects, and high economic and therapeutic applicability of patients. It is worthy of clinical promotion.