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目的:探讨烟雾病的发生与自身免疫性疾病是否存在一定的联系。方法:对402例烟雾病抗核抗体谱检测结果进行回顾性分析。结果:402例烟雾病确诊病例中,有112位患者抗核抗体谱检测结果中存在阳性结果,阳性率为27.86%。其中,抗dsDNA、抗CB、抗Sm、抗SS-A、抗SS-B、抗Jo-1、抗RO-52、抗ScL-70、抗RIB、抗PM-sd、抗nRNP、抗PCNA、抗Nuc、抗HI、抗M2抗体在阳性病例中所占百分比分别为16.07%、1.79%、5.36%、17.86%、7.14%、5.36%、13.39%、5.36%、7.14%、4.46%、2.68%、11.61%、6.25%、8.93%和8.04%。结论:烟雾病患者中抗核抗体阳性率较高,自身免疫性疾病可能是烟雾病发生的重要诱因之一。
Objective: To explore whether the occurrence of moyamoya disease and autoimmune diseases have some connection. Methods: 402 cases of moyamoya disease anti-nuclear antibody test results were retrospectively analyzed. Results: Of the 402 cases diagnosed with moyamoya disease, 112 cases had positive results of antinuclear antibody test, the positive rate was 27.86%. Anti-SS-B, anti-Jo-1, anti-RO-52, anti-ScL-70, anti-RIB, anti- PM-sd, anti-nRNP, anti- PCNA, anti- The percentage of anti-Nuc, anti-HI and anti-M2 antibodies in the positive cases were 16.07%, 1.79%, 5.36%, 17.86%, 7.14%, 5.36%, 13.39%, 5.36%, 7.14%, 4.46%, 2.68% , 11.61%, 6.25%, 8.93% and 8.04% respectively. Conclusion: The positive rate of antinuclear antibodies in patients with moyamoya disease is high. Autoimmune diseases may be one of the important causes of moyamoya disease.