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甲福明(Metformin,二甲双胍)是50年代后期开发的降血糖药,可单独或与磺酰脲类联合用于治疗非胰岛素依赖性糖尿病(NIDDM).本文综合报道了1977—1991年间瑞典甲福明的药物利用资料及其与甲福明相关的乳酸酸中毒的发生率.1977—1991年间,瑞典甲福明的处方从1.0DDD/1000居民·天增加到1.6DDD/1000居民·天,同时,每天的处方用量则从1.5g减少至1.25g左右,因此,使用甲福明的患者实际上从约10000人年/年增加到了22000人年/年.1977—1991年间,瑞典药物不良反应咨询委员会(SADRAC)共收到与甲福明应用有关的不良反应
Metformin (metformin) is a hypoglycemic drug developed in the late 1950s and can be used alone or in combination with sulfonylureas for the treatment of non-insulin-dependent diabetes mellitus (NIDDM) .In this paper, Ming drug use profile and its incidence of lactic acidosis associated with metformin, 1977 to 1991, prescription of metformin in Sweden increased from 1.0DDD / 1000 residents day to 1.6DDD / 1000 resident days, meanwhile , The daily prescription dosage was reduced from 1.5 g to about 1.25 g, so the number of patients using metformin actually increased from about 10,000 person years / year to 22,000 person years / year Between 1977 and 1991, the Swedish Adverse Drug Reaction Advisory The Board (SADRAC) received a total of adverse effects related to metformin use