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方法：雄性大鼠７２只，断奶后喂养在无特殊病原体、恒温、恒湿、定时光照的动物房。于１４周龄时，随机分成能量限制（ＣＲ）与自由进食（ＡＬ）组，ＣＲ鼠接受饲料能量为ＡＬ鼠的６０％。至１８周龄时，分批处死动物并测其体重、血糖、胰岛素、果糖胺、糖化白蛋白、总蛋白、白蛋白、球蛋白等。结果：与ＡＬ鼠比较，ＣＲ鼠的血糖、胰岛素、果糖胺及糖化血清白蛋白浓度显著降低，体重及肝重也显著下降；两组动物的果糖胺与糖化白蛋白存在显著性相关；血清蛋白浓度两组间无显著差异。结论：ＣＲ可显著改变大鼠的糖代谢，并可能通过降低大鼠血糖及胰岛素浓度、减少非酶糖化蛋白形成而发挥延缓机体老化，进而延长寿命的作用
Methods: Seventy two male rats were weaned and fed in animal houses without any special pathogens, constant temperature, constant humidity and regular light. At 14 weeks of age, rats were randomly divided into CR and AL groups, and CR rats received 60% of the AL diet. At 18 weeks of age animals were sacrificed and their body weights, blood glucose, insulin, fructosamine, glycated albumin, total protein, albumin, globulin and the like were measured. Results: The blood glucose, insulin, fructosamine and glycosylated serum albumin of CR rats were significantly lower than those of AL rats, and body weight and liver weight were also significantly decreased. There was a significant correlation between fructosamine and glycated albumin There was no significant difference in concentration between the two groups. CONCLUSION: CR can significantly change the glucose metabolism in rats, and may play an important role in delaying the aging of the body and prolonging the lifespan by reducing the blood glucose and insulin concentration in rats and reducing the formation of non-enzymatic glycated proteins