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目的分析血清及房水中白细胞介素-6(interleukin-6,IL-6)水平与糖尿病性视网膜病变(diabetic retinopathy,DR)的相关性,探讨IL-6在DR发生、发展中的作用。方法60例2型糖尿病患者(实验组),其中20例20眼无DR(non-DR,NDR)为NDR组,20例20眼非增生性DR(non-proliferative DR,NPDR)为NPDR组,20例20眼增生性DR(proliferative DR,PDR)为PDR组;健康老年性白内障患者20例20眼为对照组。采用电化学发光法检测各组血清及房水中IL-6水平,并进行比较。结果 NDR组、NPDR组、PDR组血清IL-6水平分别为(3.72±1.50)、(4.56±2.33)、(4.52±1.97)ng/L,对照组为(3.50±2.24)ng/L,实验组与对照组比较差异无统计学意义(F=1.430,P=0.240);NDR组、NPDR组和PDR组房水IL-6水平分别为(128.42±32.22)、(205.15±25.15)、(1 618.00±42.66)ng/L,对照组为(115.80±29.97)ng/L,实验组与对照组比较差异有统计学意义(F=9 851.950,P=0.000);NDR组房水IL-6水平与对照组比较差异无统计学意义(P>0.05),NPDR组与PDR组房水IL-6水平均高于对照组(P<0.01),且随眼部病情加重,有增高趋势(P<0.01)。结论房水IL-6水平的表达与DR程度相关。
Objective To analyze the correlation between interleukin-6 (IL-6) and diabetic retinopathy (DR) in serum and aqueous humor and to explore the role of IL-6 in the development and progression of DR. Methods Sixty patients with type 2 diabetes mellitus (experimental group), 20 of 20 non-DR (NDR) NDR group and 20 20 non-proliferative diabetic (NPDR) NPDR group, Twenty eyes of 20 patients with proliferative DR (PDR) were treated with PDR. 20 eyes of 20 healthy elderly patients with cataract were selected as the control group. The levels of IL-6 in serum and aqueous humor of each group were detected by electrochemiluminescence and compared. Results Serum levels of IL-6 in NDR group, NPDR group and PDR group were (3.72 ± 1.50), (4.56 ± 2.33) and (4.52 ± 1.97) ng / L respectively, while those in control group were (3.50 ± 2.24) ng / There was no significant difference between the two groups (F = 1.430, P = 0.240). The levels of IL-6 in the NDR group, NPDR group and PDR group were (128.42 ± 32.22), 618.00 ± 42.66 ng / L, and the control group was (115.80 ± 29.97) ng / L, the difference between the experimental group and the control group was statistically significant (F = 9851.950, P = 0.000) Compared with the control group, there was no significant difference (P> 0.05). IL-6 level in aqueous humor of NPDR group and PDR group were higher than that of the control group (P <0.01), and increased with the severity of eye disease (P < 0.01). Conclusion The level of IL-6 in aqueous humor is related to the degree of DR.