脑内出血后的远期死亡率

• 作 者: Flaherty M.L Haverbusch M. Sekar P. 张慧
• 机 构: University of Cincinnati Medical Center MSB 231 Albert Sabin Way Cincinnati OH 45267-0525 United St
• 出 处: 世界核心医学期刊文摘(神经病学分册)
• 发表日期: 2006年09期
• 关键词: 脑内出血 非外伤性 抗凝剂 样本人群 那提 资料收集 肯塔基州

Objective: To characterize long-term mortality following intracerebral hemorrhage (ICH) in two large population-based cohorts assembled more than a decade apart. Methods: All patients age ≥18 hospitalized with nontraumatic ICH in the Greater Cincinnati/Northern Kentucky area were identified during 1988 (Cohort 1) and from May 1998 to July 2001 and August 2002 to April 2003 (Cohort 2). Mortality was tabulated using actuarial methods and compared with a log-rank test. Results: There were 183 patients with ICH in Cohort 1 and 1,041 patients in Cohort 2. Patients in Cohort 1 were more likely to be white (p = 0.024) and undergo operation for their ICH (p = 0.002), whereas patients in Cohort 2 were more commonly on anticoagulants (p < 0.001). Among patients in Cohort 1, mortality at 7 days, 1 year, and 10 years was 31, 59, and 82%. Among patients in Cohort 2, mortality at 7 days and 1 year was 34 and 53%. Mortality rates did not differ between cohorts by logrank test (p = 0.259). Conclusions: Intracerebral hemorrhage (ICH) mortality did not improve significantly between study periods. Operation for ICH became less frequent, whereas anticoagulant-associated ICH became more common.

Objective: To characterize long-term mortality following intracerebral hemorrhage (ICH) in two large population-based cohorts assembled more than a decade apart. Methods: All patients age ≥18 hospitalized with nontraumatic ICH in the Greater Cincinnati / Northern Kentucky area were identified during 1988 (Cohort 1) and from May 1998 to July 2001 and August 2002 to April 2003 (Cohort 2). Mortality was tabulated using actuarial methods and compared with a log-rank test. Results: There were 183 patients with ICH in Cohort 1 and 1,041 patients in Cohort 2. Patients in Cohort 1 were more likely to be white (p = 0.024) and undergo operations for their ICH (p = 0.002), patients in Cohort 2 were more commonly on anticoagulants (p <0.001). Among Patients in Cohort 1, mortality at 7 days, 1 year, and 10 years was 31, 59, and 82%. Among patients in Cohort 2, mortality at 7 days and 1 year was 34 and 53%. Mortality rates did not differ between cohorts by logrank test (p = 0.259). Conclusio ns: Intracerebral hemorrhage (ICH) mortality did not improve significantly between study periods. Operation for ICH became less frequent, yet anticoagulant-associated ICH became more common.