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目的:探讨造口涂膜剂对慢性皮炎的治疗作用及抗磷酸组胺的止痒作用。方法:采用二硝基氯苯(DNCB)皮肤涂抹法制造实验动物慢性皮炎模型,通过观察造口涂膜剂对实验动物病变皮肤的肿胀度、损伤程度,对造口涂膜剂抗慢性皮炎效果进行初步评价;采用皮下注射磷酸组胺的方法制造实验动物瘙痒模型,通过观察动物瘙痒程度的差异,对造口涂膜剂的止痒作用进行初步评价。结果:造口涂膜剂对动物的慢性皮炎有明显的抑制作用,能显著地减轻皮肤肿胀、局部炎症反应,并能对抗组胺所致的皮肤瘙痒反应。结论:造口涂膜剂对慢性皮炎的动物模型的抗炎、止痒疗效确切,非常具有临床开发价值。
Objective: To investigate the therapeutic effect of ostomycin on chronic dermatitis and the antipruritic effect of histamine phosphate. Methods: The model of chronic dermatitis was established by DNCB skin smear method. By observing the swelling degree and damage degree of stoma, the anti-chronic dermatitis effect of stoma coating agent The pruritus models of experimental animals were made by subcutaneous injection of histamine phosphate and the antipruritic effect of stoma was evaluated by observing the difference of pruritus degree of animals. Results: Stoma ostomycin significantly inhibited chronic dermatitis in animals and significantly reduced skin swelling and local inflammatory response. It also counteracted skin pruritus induced by histamine. Conclusion: The anti-inflammatory and antipruritic effects of ostomycin on animal model of chronic dermatitis are exact and very valuable for clinical development.