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胰岛素抵抗是肥胖的标志，β细胞功能也会随之发生改变。2020年4月，n JCEM杂志发表了一篇题为《减重改善重度肥胖伴空腹糖耐量受损患者β细胞功能：一个治疗窗》的文章[Rothberg AE, Herman WH, Wu C, et al. J Clin Endocrinol Metab, 2020，105(4)：e1621-e1630]。该文为开放获取文章，本文对其进行了中文编译。该文通过对58例重度肥胖伴正常糖耐量、空腹血糖受损和早期2型糖尿病的患者以及13名正常体重、正常糖耐量个体进行研究，评估医学减重对胰岛素敏感性、胰岛素分泌量和β细胞功能的影响。结果表明短期减重能够改善肥胖伴空腹糖耐量受损患者的β细胞功能，效果可维持2年，提示这些患者可能存在一个治疗窗口。n “,”Insulin resistance is a hallmark of obesity, and β-cell function may adapt to it. This paper is the Chinese translation of “ Weight Loss Improves β-Cell Function in People with Severe Obesity and Impaired Fasting Glucose: A Window of Opportunity” , published on n J Clin Endocrinol Metab [Rothberg AE, Herman WH, Wu C, et al. J Clin Endocrinol Metab, 2020, 105(4): e1621-e1630], which is open-accessed to all the readers. In this study, 58 subjects with severe obesity accompanied by normal glucose tolerance(NGT), impaired fasting glucose(IFG), and early type 2 diabetes(T2DM)as well as 13 subjects with normal weight and NGT were included, with the aim to assess the effect of medical weight loss on insulin sensitivity, insulin secretion, and β-cell function. The results suggest that short-term weight loss may improve β-cell function in subjects with obesity accompanied by IFG, which may remain through 2 years, indicating a window of opportunity for treatment.n