Determination of atractylon in rat plasma by a GC-MS method and its application to a pharmacokinetic

• 作 者: Han Yan Yuanyuan Sun Yuying Ma
• 机 构: SchoolofPharmacy,SchoolofPharmaceuticalEngineering
• 出 处: 药物分析学报：英文版
• 发表日期: 2015年5期
• 关键词: 气相色谱-质谱法 药代动力学 苯乙酮 苍术 血浆 大鼠 测定 应用 AtractylonAtractylodisRat plasmaPharmacokineti
• 基金项目: supported by the National Natural Science Foundation of China(Nos.81073143 and 81373926),Research Fund for the Doctoral Program of Higher Education of China(No. 20092134110004)

A sensitive and selective method based on gas chromatography hyphenated to mass spectrometry(GCMS) was developed and validated for the determination of atractylon in rat plasma.Plasma samples were processed by liquid-liquid extraction with ethyl acetate-n