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目的探讨胸苷酸合成酶(TS)表达与胃癌临床病理特征的关系。方法采用免疫组化方法检测了163例胃癌组织中TS蛋白的表达。结果 163例胃癌组织中TS表达阳性率为42.9%,其表达与性别、年龄、病变部位、分化程度、肿瘤浸润深度、淋巴结转移阳性、有无远处转移均无明显关系(P>0.05);但进展期患者TS表达阳性率显著高于早期患者(P<0.01)。TS表达阳性者3年随访生存率为62.9%,明显低于TS表达阴性者的77.4%(P<0.05);但在126例进展期胃癌中,TS表达阳、阴性者的生存率无明显差异。结论 TS表达阳性提示胃癌患者预后较差,但更能够在基于5-FU的辅助化疗中获益。
Objective To investigate the relationship between thymidylate synthase (TS) expression and clinicopathological features of gastric cancer. Methods The expression of TS protein in 163 cases of gastric carcinoma was detected by immunohistochemistry. Results The positive expression rate of TS in 163 cases of gastric carcinoma was 42.9%. There was no significant relationship between the expression of TS and the distant metastasis (P> 0.05). The expression of TS was positively correlated with gender, age, location of lesions, differentiation, depth of tumor invasion, lymph node metastasis, However, the positive rate of TS expression in advanced stage patients was significantly higher than that in early stage patients (P <0.01). The 3-year follow-up survival rate of TS positive was 62.9%, which was significantly lower than that of TS negative 77.4% (P <0.05). However, in 126 cases of advanced gastric cancer, there was no significant difference in survival rate between TS positive and negative TS . Conclusion The positive expression of TS suggests that the prognosis of patients with gastric cancer is poor, but is more able to benefit from adjuvant chemotherapy based on 5-FU.