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目的:探讨n DEPDC5 rs5998152单核苷酸多态性与丙型肝炎病毒(hepatitis C virus, HCV)相关疾病发生风险的关系。n 方法:纳入2016年9月至2017年7月就诊于天津市第二人民医院诊断为HCV感染的患者，分为慢性丙型肝炎组(肝炎组)、慢性丙型肝炎肝硬化组(肝硬化组)和慢性丙型肝炎肝硬化合并肝癌组(肝癌组)。应用MALDI-TOF MS质谱技术检测样本基因组的n DEPDC5 rs5998152位点的基因多态性，同时回顾病历资料。根据正态分布情况采用t检验、方差分析或者非参数检验分析计量资料，采用卡方检验分析计数资料，采用Logistic回归分析单核苷酸多态性与疾病发生风险的相关性。n 结果:共入组147例患者，其中慢性丙型肝炎患者55例、慢性丙型肝炎肝硬化患者54例、慢性丙型肝炎肝硬化合并肝癌患者48例。肝硬化组和肝癌组患者的丙氨酸氨基转移酶、天冬氨酸氨基转移酶、甲胎蛋白、总胆红素水平以及肝性脑病的比例均显著高于肝炎组(n P<0.05)，并且肝癌组的总胆红素及甲胎蛋白水平也显著高于肝硬化组(n P 0.05)。肝硬化和肝癌组的C等位基因频率显著高于肝炎组，差异具有统计学意义( n P<0.05)，而且Logistic回归模型分析显示携带n DEPDC5 rs5998152 C等位基因和TC+CC基因型的慢性丙型肝炎患者进展为丙型肝炎相关肝硬化和肝癌的风险显著增加，二者具有显著相关性(n P<0.05)。n DEPDC5 rs5998152等位基因频率在肝硬化和肝癌组之间分布无显著差异，其与丙型肝炎肝硬化进展为肝癌的风险无显著相关性。n 结论:DEPDC5 rs5998152单核苷酸多态性可能是慢性丙型肝炎患者发生肝硬化和肝癌的风险因素之一。n “,”Objective:To examine the correlation between n DEPDC5 rs5998152 variants and the risk of hepatitis C virus (HCV) related liver diseases onset.n Methods:Patients with chronic hepatic diseases diagnosed as HCV infection in Tianjin Second People′s Hospital from September 2016 to July 2017 were enrolled in the study and were divided into chronic hepatitis C (CHC) group, CHC related liver cirrhosis (LC) group and hepatocellular carcinoma (HCC) group. n DEPDC5 rs5998152 was genotyped using the matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) assay and the case data were reviewed. T test, analysis of variance (ANOVA), and non-parametric test were used to perform the comparison of the quantitative data between groups according to normally distributed or not. Chi-square test was used to examine the different distribution of enumeration data between groups. Logistic regression analysis was employed to analyze the correlation between the genetic polymorphism and risk of LC and HCC.n Results:A total of 147 patients were included in this study, with 55 in CHC group, 54 in LC group and 48 in HCC group. The levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST), α-fetoprotein (AFP), total bilirubin and rate of hepatic encephalopathy were significantly higher in LC and HCC groups compared to CHC group( n P<0.05). And the levels of AFP and total bilirubin were significantly higher in HCC group than LC group (n P 0.05). The frequency of the C allele at n DEPDC5 rs5998152 was higher in LC and HCC subjects than in CHC patients (n P<0.05) and the Logistic analysis indicated that CHC individuals with C allele and TC+ CC genotypes showed higher risk of LC and HCC compared with those with T allele and TT genotype (n P<0.05). In addition, the difference ofn DEPDC5 rs5998152 allele frequency was not significant between LC and HCC groups and it was not correlated with risk of HCC for LC patients.n Conclusions:DEPDC5 rs5998152 may be a risk factor of progression to LC and HCC in the Chinese Han patients with CHC.n