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目的 :观察肝硬化患者甲状腺素的变化 ,探讨其临床意义。方法 :对 70例肝硬化失代偿期、40例肝硬化代偿期和 30例健康者进行三碘甲状腺原氨酸 (T3 )、甲状腺素 (T4 )、rT3 及促甲状腺素 (TSH)观察。结果 :肝硬化患者甲状腺水平和正常对照组相比 ,T3 、T4 明显下降 ,rT3 明显升高 ,T3 /rT3 比值降低 ,TSH轻度升高(P <0 0 5 ) ;肝硬化失代偿期患者与代偿期患者相比 ,T3 、T4 降低 ,rT3 、TSH升高 ,其变化有显著性差异 (P <0 0 5 )。结论 :肝硬化患者出现血清T3 、T4 降低和rT3 升高及TSH轻度升高与其病期有关 ,甲状腺素水平变化是反映病情的重要指标。
Objective: To observe the changes of thyroxine in cirrhotic patients and explore its clinical significance. Methods: 70 patients with decompensated liver cirrhosis, 40 patients with decompensated liver cirrhosis and 30 healthy subjects were observed for triiodothyronine (T3), thyroid hormone (T4), rT3 and thyrotropin (TSH) . Results: The thyroid level of patients with cirrhosis was significantly lower than that of the normal control group (P <0.05). The levels of T3 and T4 were significantly decreased, while the levels of T3 / rT3 and T3 were slightly increased (P <0.05) Patients with compensated patients, T3, T4 decreased, rT3, TSH increased, the change was significantly different (P <0 05). Conclusions: Serum T3, T4, elevated rT3 and mild TSH are correlated with their disease stage in patients with cirrhosis. The change of thyroxine level is an important indicator of the disease.