β-胡萝卜素包合物的制备

• 作 者: 梁天天 陈志群 胡富强 周美华
• 机 构: 浙江省药学会,杭州默沙东制药有限公司,浙江医科大学药学院
• 出 处: 中国药学杂志
• 发表日期: 1998年09期
• 关键词: β-胡萝卜素 包裹率 包合物 研磨法 差示热分析 新型药物载体 机械研磨 抗氧剂 工艺条件 饱和水溶液法

目的：探讨制剂β胡萝卜素包合物（βＣＩＣ）的工艺条件对包合物的影响。方法：以β环糊精（βＣＤ）为载体，用饱和水溶液法和机械研磨法制备βＣＩＣ，考察抗氧剂对机械研磨法制备βＣＩＣ包裹率和收得率的影响，差示热分析研究βＣ特征吸收峰，分光光度法测定βＣ含量。结果：机械研磨法可提高βＣ的包裹率和收得率，在机械研磨法中加入适量抗氧剂可进一步提高βＣ的包裹率和收得率。结论：机械研磨法有希望成为新型药物载体工业化生产的有效途径

Objective: To investigate the effect of preparation conditions on the inclusion compound of β-carotene inclusion complex (βCIC). Methods: βcyclodextrin (βCD) as a carrier, with saturated aqueous solution and mechanical grinding method prepared β  C  IC, antioxidant resistance of mechanical grinding method to prepare β  C  IC package rate and income Rate of influence, differential thermal analysis of β-C characteristic absorption peak, spectrophotometric determination of β C content. Results: The mechanical grinding method can improve the β-C package rate and yield, in the mechanical grinding method by adding an appropriate amount of antioxidants can further improve the β-C package rate and yield. Conclusion: The mechanical grinding method is promising to be an effective way to industrialize the production of new drug carriers