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目的 比较奥曲肽与垂体后叶素治疗食管静脉曲张破裂出血 (EVB)的临床疗效。方法 将 93例食管静脉曲张破裂出血的患者随机分为 2组 ,奥曲肽组予奥曲肽 10 0 μg静注 ,继以 2 5μg/h的速度持续静滴 ,维持 4 8h ;垂体后叶素组予垂体后叶素 0 .2～ 0 .4u/min持续静滴 2 4h ,血止后减半量维持 2 4h。观察 2组的临床疗效及不良反应。结果 奥曲肽组总有效率为 81.3% ,止血时间为 9.2 8± 7.4 0h ;垂体后叶素组总有效率为 60 % ,止血时间约为 2 6.50± 19.82h ,两组比较 ,有显著差异。结论 奥曲肽治疗食管静脉曲张破裂出血疗效快、止血率高 ,且副作用少 ,比垂体后叶素优越 ,但价格较贵 ,对经济条件好的患者提倡使用该药
Objective To compare the clinical efficacy of octreotide and vasopressin in the treatment of esophageal variceal bleeding (EVB). Methods Ninety-three patients with esophageal variceal bleeding were randomly divided into two groups. The patients in the octreotide group were given intravenous injection of octreotide at a dose of 10 μg intravenously, followed by intravenous infusion at a rate of 25 μg / h for 48 h. The pituitrin group was given pituitary Vasopressin 0. 2 ~ 0. 4u / min continuous infusion of 2 4h, blood halved half of the amount to maintain 24h. The clinical efficacy and adverse reactions in 2 groups were observed. Results The total effective rate was 81.3% in octreotide group and 9.2 8 ± 7.4 0 h in hemostasis group. The total effective rate in vasopressin group was 60% and the bleeding time was about 2.50 ± 19.82 hours. There was significant difference between the two groups. Conclusion Octreotide treatment of esophageal variceal bleeding faster, hemostatic rate, and fewer side effects than pituitary vasopressin superior, but more expensive, good economic conditions in patients with the promotion of the use of the drug