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目的:观察益气健脾中药对二甲基肼诱导的大肠肿瘤小鼠模型在抑制肿瘤生成方面的作用。方法:将80只小鼠随机分为模型对照组及益气健脾中药高、中、低剂量组,以二甲基肼诱导小鼠大肠肿瘤模型,药物干预组予以灌胃益气健脾汤。计算、检测各组小鼠荷瘤数、体质量及血红蛋白含量。结果:高剂量组小鼠的平均荷瘤数、癌结节发生率及肠癌发生率低于模型对照组(P<0.05);高剂量组小鼠的血红蛋白含量高于中剂量组(P<0.05)及模型对照组(P>0.05);各组之间体质量无差异(P>0.05)。结论:早期运用益气健脾汤能够抑制二甲基肼诱导的小鼠大肠肿瘤的发生,并提高小鼠的机体功能。
Objective: To observe the effect of Qi-invigorating and invigorating spleen Chinese medicine on the inhibition of tumorigenesis by dimethyl hydrazine-induced mouse model of colorectal cancer. Methods: Eighty mice were randomly divided into model control group and high, medium and low dose Yiqi Jianpi Chinese medicine group, dimethyl hydrazine induced mouse colorectal tumor model, the drug intervention group was given Yiqi Jianpi Decoction . Calculate, detect the number of tumor-bearing mice in each group, body mass and hemoglobin content. Results: The average number of tumor cells, the incidence of cancer nodules and the incidence of colorectal cancer in high dose group mice were lower than those in model control group (P <0.05). The hemoglobin content in high dose group mice was higher than that in middle dose group (P < 0.05) and model control group (P> 0.05). There was no difference in body weight between groups (P> 0.05). Conclusion: The early use of Yiqi Jianpi Decoction can inhibit dimethyl hydrazine-induced colorectal tumor and improve the function of mice.