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目的 :探讨细胞增殖抗原标记物 (Ki6 7)和血管内皮生长因子 (VEGF)在喉鳞状细胞癌中的表达及其相互关系。方法 :用免疫组织化学方法研究Ki6 7和VEGF在 4 0例喉鳞状细胞癌组织 (喉癌组 )和 5例正常喉黏膜标本 (对照组 )中的表达。结果 :Ki6 7和VEGF在喉癌组中的表达高于对照组 (P <0 .0 1) ;在有淋巴结转移的喉鳞状细胞癌中的表达高于无淋巴结转移者 (分别为P<0 .0 5和P <0 .0 1) ;Ki6 7和VEGF在不同年龄、性别患者中的表达差异无统计学意义 (P >0 .0 5 ) ;Ki6 7和VEGF的表达与喉癌T分期有关 (P <0 .0 5 ) ,且Ki6 7和VEGF的表达之间存在正相关关系 (r =0 .82 3,P <0 .0 1)。结论 :Ki6 7和VEGF均可作为反映喉鳞状细胞癌生物学行为的客观参考指标 ,两者相结合可有助于喉癌的诊断、分期的判断和治疗方案的制定。
Objective: To investigate the expression and correlation of Ki67 and VEGF in laryngeal squamous cell carcinoma (LSCC). Methods: The expressions of Ki6 7 and VEGF in 40 laryngeal squamous cell carcinoma (LSCC) and 5 normal laryngeal mucosa specimens (control group) were studied by immunohistochemistry. Results: The expression of Ki67 and VEGF in laryngeal squamous cell carcinoma was significantly higher than that in control group (P <0.01). The expression of Ki67 and VEGF in laryngeal squamous cell carcinoma with lymph node metastasis was higher than that without lymph node metastasis (P < 0. 05 and P <0.01). There was no significant difference in the expression of Ki6 7 and VEGF in different age and gender (P> 0.05) There was a positive correlation between the expression of Ki67 and VEGF (r = 0.82 3, P <0.01). Conclusion: Both Ki6 7 and VEGF can be used as objective reference indexes to reflect the biological behavior of laryngeal squamous cell carcinoma. The combination of both can be helpful for the diagnosis of laryngeal carcinoma, the staging of judgment and the treatment plan.