铅对心肌酶、钠钾泵、钙镁泵活性以及肾素、血管紧张素Ⅱ活性影响探讨

• 作 者: 邹和建 丁钺 徐麦玲 黄开莲 曹新莉
• 机 构: 上海医科大学附属华山医院职业病科,上海医科大学附属华山医院职业病科,上海医科大学附属华山医院职业病科,上海医科大学附属华山医院职业病科,上海医科大学附属华山医院职业病科 200040,200040,2
• 出 处: 中国工业医学杂志
• 发表日期: 1994年01期
• 关键词: 血管紧张素Ⅱ 肾素 铅作业工人 活性影响 血浆肾素活性 钠-钾泵 心肌酶活性 心肌细胞损伤 血铅水平 血清心肌酶

本研究同时测定了铅作业组、非铅作业组两组对象红细胞钠-钾泵、钙-镁泵活性、血浆肾素活性、血管紧张素Ⅱ以及血清心肌酶CMB、CPK、LDH活性。结果发现两组间钠-钾汞、钙-镁泵活性以及血浆肾素活性、血管紧张素Ⅱ均无显著差异,但铅作业组CMB水平与血铅水平呈正相关,提示铅负荷增加情况下可能导致心肌细胞损伤。心肌细胞受损是铅作业工人心功能受损的可能机制之一。

In this study, the activities of erythrocyte sodium-potassium pump, calcium-magnesium pump, plasma renin, angiotensin Ⅱ and serum myocardial enzymes CMB, CPK and LDH were also determined in both lead and non-lead groups. The results showed that there was no significant difference between the two groups in sodium-potassium mercury, calcium-magnesium pump activity, plasma renin activity and angiotensin II, but there was a positive correlation between CMB level and blood lead level in the lead group, suggesting that the lead load may increase Lead to myocardial cell injury. Myocardial cell damage is one of the possible mechanisms of impaired cardiac function in lead workers.