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目的 :分析胃腺癌组织的低密度脂蛋白受体 (LDLR)活性 ,研究其与癌组织分化程度的关系。方法 :以12 5I LDL为配体 ,采用受体放射性配体结合分析法测定胃腺癌及其周边组织LDLR活性。结果 :胃腺癌组织与其周边正常组织LDLR活性差异明显 (P <0 .0 1) ,但LDLR的亲合性和特异性无明显改变 ;分化好与分化差的腺癌组织的LDLR活性差异显著 (P <0 .0 1)。结论 :胃腺癌组织LDLR活性明显增高 ,组织分化越低 ,LDLR活性越高
OBJECTIVE: To analyze the activity of low density lipoprotein receptor (LDLR) in gastric adenocarcinoma and to investigate its relationship with the degree of differentiation of cancer. Methods: The LDLR activity of gastric adenocarcinoma and its adjacent tissues was determined by using 125I LDL as a ligand and radioligand binding assay. Results: There were significant differences in LDLR activity between gastric adenocarcinoma tissues and surrounding normal tissues (P <0.01), but the affinity and specificity of LDLR did not change significantly. LDLR activity of differentiated and poorly differentiated adenocarcinomas was significantly different P <0 .0 1). Conclusion: The activity of LDLR in gastric adenocarcinoma was significantly increased. The lower the differentiation, the higher the activity of LDLR