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作者单用去甲氧柔红霉素(IDR)口服治疗20例未经治疗的老年(65-79岁)AML患者,其中男12例,女8例,70岁以上者13例,按FAB分类:5例M1;9例M2;5例M4;1例M5。治疗前WBC计数为I-168×10~9/L(中位数12),Plt8-230×10~9/L(中位数33)。口服IDR,30mg/m~2/d×3d(1个疗程),15例仅治疗1个疗程,5例在第15天开始第2疗程。8例CR(40%),而其中6例仅用1个疗程,余2例治疗2个疗程。70岁以下CR率为57%(4/7),70岁以上为31%(4/13)。1例在治疗的第5天死于呼吸道感染,4例死于再障合并感染。1例在死亡的当时进行骨髓检查,没有发现有白血病细胞的浸润。7例无效(35%)。
The authors treated 20 untreated AML patients (aged 65-79 years) orally with dextromethorphan (IDR) alone, 12 of whom were males and 8 were females, 13 were over 70 years of age and were classified according to FAB : 5 cases of M1; 9 cases of M2; 5 cases of M4; 1 case of M5. WBC counts before treatment were I-168 × 10 ~ 9 / L (median 12) and Plt8-230 × 10 ~ 9 / L (median 33). Oral IDR, 30mg / m ~ 2 / d × 3d (1 course), 15 cases only for one course of treatment, 5 cases in the first 15 days of the second course of treatment. 8 cases of CR (40%), of which 6 cases only one course of treatment, the remaining two cases of treatment of 2 courses. CR rates below 70 years old were 57% (4/7) and over 70 years old 31% (4/13). One patient died of respiratory infection on the fifth day of treatment and four died of aplastic anemia. One case had a bone marrow examination at the time of death and no leukemia cell infiltration was found. Seven cases were ineffective (35%).