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目的探讨放射性碘治疗对分型甲状腺癌患者生命质量的改善效果。方法回顾性分析140例分型甲状腺癌患者的临床病理资料,患者均采用甲状腺全切除术+患侧中央组淋巴结清扫治疗;术后采用放射性碘治疗者设为观察组;同时选择同期入院健康体检健康人群90例为对照组。结果功能领域:观察组患者首次治疗后情绪功能评分为(78.27±10.71)分,明显低于治疗前[(82.41±14.65)分],P<0.05;症状领域:观察组患者治疗后气促、便秘评分分别为[(8.49±14.57)分、(8.52±21.75)分],明显低于治疗前[(15.97±18.74)分、(11.27±22.86)分],P<0.05。观察组患者各功能领域评分、总体健康状况均明显低于对照组,P<0.05;除腹泻、便秘外,其余各症状领域评分均明显较对照组低,P<0.05。结论应用放射性碘治疗分化型甲状腺癌对其生命质量无负面影响,同时可促进患者气促及便秘好转,患者情绪功能变差可能与药物及治疗环境有关。不管是放射性碘治疗前还是治疗后,分化型甲状腺癌患者生命质量均较健康人群差。
Objective To investigate the effect of radioactive iodine treatment on the quality of life of patients with subtype of thyroid cancer. Methods The clinicopathological data of 140 patients with thyroid carcinoma were retrospectively analyzed. All patients underwent total thyroidectomy + ipsilateral central lymph node dissection. The patients treated with radioactive iodine were treated as observation group. At the same time, 90 healthy people as control group. Results Functional areas: The score of emotional function in the observation group after first treatment was (78.27 ± 10.71) points, which was significantly lower than that before treatment (82.41 ± 14.65) points, P <0.05. Symptoms were: The scores of constipation were [(8.49 ± 14.57) points, (8.52 ± 21.75) points], which were significantly lower than those before treatment [(15.97 ± 18.74) points, (11.27 ± 22.86) points], P <0.05. The score of each functional area and overall health status in the observation group were significantly lower than those in the control group (P <0.05). Except diarrhea and constipation, scores of other symptoms were significantly lower than those in the control group (P <0.05). Conclusions The application of radioactive iodine in the treatment of differentiated thyroid cancer has no negative impact on the quality of life of patients with thyroid cancer. At the same time, it can promote the improvement of shortness of breath and constipation. The deterioration of emotional function may be related to the drug and the treatment environment. Whether before or after radioactive iodine treatment, the quality of life of differentiated thyroid cancer patients were worse than healthy people.