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目的探讨T2DM未合并冠心病患者血浆B型脑钠肽(BNP)与FPG的相关性。方法选取经冠脉造影排除冠心病的T2DM患者175例,按照FPG水平分为<7mmol/L组、7~9mmol/L组和>9mmol/L组,检测各组BNP等指标。结果 FPG<7mmol/L组与其他两组比较,BNP水平差异有统计学意义[(16.02±5.03)vs(14.98±4.73),(14.12±4.65)pg/ml](P<0.01)。随着FPG水平的增高,BNP浓度降低。Pearson相关分析显示,BNP与FPG呈负相关(r=-0.775,P<0.01)。多元线性回归分析显示,年龄、SBP、SUA、BMI、FPG、HbA1c是BNP的影响因素(P<0.05)。结论 BNP可能参与了血糖调节。
Objective To investigate the correlation between plasma B-type natriuretic peptide (BNP) and FPG in patients with T2DM without coronary heart disease. Methods One hundred and seventy-five patients with T2DM who underwent coronary angiography to exclude coronary heart disease were enrolled in this study. The levels of BNP in each group were measured according to the level of FPG and were divided into 7mmol / L group, 7 ~ 9mmol / L group and> 9mmol / L group. Results Compared with other two groups, the levels of BNP in FPG <7mmol / L group were significantly different ([(16.02 ± 5.03) vs (14.98 ± 4.73), (14.12 ± 4.65) pg / ml] As FPG levels increase, BNP levels decrease. Pearson correlation analysis showed that BNP was negatively correlated with FPG (r = -0.775, P <0.01). Multivariate linear regression analysis showed that age, SBP, SUA, BMI, FPG and HbA1c were the influencing factors of BNP (P <0.05). Conclusion BNP may be involved in the regulation of blood glucose.