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作者在对16～39岁妇女心血管病死亡率的对照研究中意外发现,近期应用精神药物的年轻妇女其心肌梗塞(MI)的危险性增加(相对危险度16.9,95%,可信限3.9～72.8)。提示心血管疾病与精神疾病发病率之间存在联系。研究选择英国和威尔士1986年1月～1988年12月间因 MI 致死的16～39岁妇女作为调查对象。其死亡证明由人口普查局提供,通过医院纪录和尸检报告证实其死因为 MI 的条件有:尸检发现冠脉血栓阻塞,组织学检查证实为近期 MI,有阳性的心电图报告或心肌酶升高。死亡原因不明者除外。
In a randomized controlled study of cardiovascular mortality in women aged 16-39, the authors found unexpectedly increased risk of myocardial infarction (MI) in young women using psychotropic drugs (relative risk, 16.9, 95%, and confidence 3.9 ~ 72.8). Suggesting a link between the prevalence of cardiovascular disease and mental illness. The study selected 16 to 39-year-old women who died of MI from January 1986 to December 1988 in the United Kingdom and Wales as their subjects. The death certificate was provided by the Census Bureau. Hospital records and autopsy reports confirmed the cause of death as MI. Coronary artery thrombosis was found at necropsy, histologically confirmed as recent MI, and positive electrocardiogram reports or elevated myocardial enzymes. Except for unknown causes of death.